Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. 2017 Apr 03; 127(4):1254-1270. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. 2011 Jan 04; 108(1):308-13. Awareness, treatment, and control of vascular risk factors among stroke survivors. 2002 Jul; 283(1):G204-11. 2009 Jan 16; 378(3):348-53. J Hepatol. J Clin Invest. 2006 Jul 27; 82(2):241-50. 2002 Nov; 70(11):6294-301. J Biol Chem. 2014 Oct 28; 83(18):1653-60. 2014 May; 146(6):1513-24. Nucleic Acids Res. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. Transforming growth factor B and hepatic fibrosis: cause or effect? J Immunol. Am J Physiol Gastrointest Liver Physiol. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. DNA. 2006 Sep; 291(3):G456-63. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. 2013 Jun; 45(6):450-9. FASEB J. J Gastroenterol. J Bone Miner Res. Mechanisms of liver fibrosis and its role in liver cancer. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. 2005 Aug; 43(2):317-23. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. 2012 Mar; 27 Suppl 2:65-8. Gastroenterology. J Gastroenterol Hepatol. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. Am J Physiol Gastrointest Liver Physiol. The future of gastroenterology and gastroenterology. Expression of human immunodeficiency virus-1 in human colonic cells. Origin of myofibroblasts in the fibrotic liver in mice. 2016 05; 139(Pt 5):e28. 2003 Jan 01; 8:d69-77. Am J Physiol Gastrointest Liver Physiol. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. 2006 May; 130(6):1564-72. J Gastroenterol Hepatol. Nat Rev Gastroenterol Hepatol. 2013 Feb 01; 12(3):381-2. 2006 May; 130(6):1562. J Clin Invest. Derived automatically from this person's publications. Hepatology. The enzymatic defect in variegate prophyria. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. The renin-angiotensin-aldosterone system in cerebral small vessel disease. Am J Physiol. 1999 09; 277(3):G671-7. Carcinogenesis. Clin Res Hepatol Gastroenterol. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Transient induction of c-jun during hepatic regeneration. 2012 Nov; 122(11):4280-2. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. Cell Host Microbe. Semin Liver Dis. Gastroenterology. David has 2 jobs listed on their profile. Front Mol Biosci. 2011 Apr; 25(4):1133-44. Acceptance Post-Bac. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. 2007 May; 132(5):1937-46. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. 1993 Feb; 17(2):287-92. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Promising Therapy Candidates for Liver Fibrosis. 1989 May; 9(5):2224-7. Gastroenterology. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. 2001 Jul; 34(1):89-100. 2006 Apr; 43(4):872-8. Infect Immun. 2011 Jul; 41(7):683-6. 2005 Sep; 230(8):573-86. 2007 Jun; 22 Suppl 1:S73-8. 1990 Feb; 10(2):689-95. 2002 May 17; 277(20):18229-37. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. 2017 10 16; 8(1):837. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. Hepatology. 2005 Mar; 39(3):181-8. Yale J Biol Med. Aliment Pharmacol Ther. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Hepatology. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. 2014 Dec; 60(6):1920-8. This graph shows the total number of publications by year. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Nucleic Acids Symp Ser. Biochim Biophys Acta. 2010 Sep; 139(3):836-45, 845.e1. Mol Cell Biol. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Aliment Pharmacol Ther. Clin Gastroenterol Hepatol. 2018 09; 68(3):918-932. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. 2017 12; 1(10):1043-1057. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. 2000 Jan; 118(1):90-100. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. N Engl J Med. J Bioenerg Biomembr. Mol Endocrinol. J Biol Chem. 2002 Sep; 132(3):441-9. 2021; 16(12):e0260721. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Proc Natl Acad Sci U S A. Hepatology. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). J Biol Chem. 1999; 66:205-22. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. 2012 Nov; 143(5):1330-1340.e1. 2012 Jul; 36(1):22-9. Identification of small molecule activators of cryptochrome. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. 2009 Mar 03; 106(9):3300-5. Hepatology. Hepatology. Proud to be part of UC San Diego and UC San Diego Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. 2016; 7:47. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Am J Pathol. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. 2020 Apr; 4(4):606-626. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. 2017 03; 15(3):463-464. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Nat Med. Cloning of murine ferrochelatase. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Biofactors. Dig Dis. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2005 Apr; 115(4):849-59. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. Nat Immunol. Clin Gastroenterol Hepatol. 2010 Sep; 139(3):987-98. 1998 09; 275(3):G387-92. 2009; 44 Suppl 19:1-7. 1999 Aug; 21(2):238-45. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Hepatology. 2020; 144(8):400-412. 2006 Nov; 291(5):G877-84. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. Circulation. Antioxid Redox Signal. 2019 07 23; 116(30):15184-15193. Hepatology. To return to the graph. Blood. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. Pharm Res. 2006 Oct; 21 Suppl 3:S84-7. 1999 03; 276(3):G591-8. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. Neurogastroenterol Motil. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. 2006 Apr; 290(4):G583-9. MELD and the practicing gastroenterologist. Arch Biochem Biophys. Migration of fibrocytes in fibrogenic liver injury. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 1990 Dec; 9(10):777-81. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Hepatology. 1988 Jan-Feb; 8(1):176-82. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. 2011 Jul; 179(1):189-98. Hepatology. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Mechanisms of fibrogenesis. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. Gastroenterology. 2014 Jul; 124(7):2921-34. Am J Physiol. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. This graph shows the number and percent of publications by field. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. 1995; 255:342-59. Liver fibrogenesis: a new role for the renin-angiotensin system. 2005 Feb; 115(2):209-18. 2003 Mar; 37(3):653-64. Am J Physiol Gastrointest Liver Physiol. 1989 Oct 05; 264(28):16957-62. 1990 Nov; 26(11):1011-23. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. Vuori will Int J Stroke. Mol Cell Biol. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. In this role, he leads the School of Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. 2014 Jan; 59(1):19-20. 1999 Oct; 18(10):751-61. Carethers will report directly to the chancellor and is part of the leadership team. 2004 Jun; 40(6):942-51. 2014 Oct; 27(5):413-25. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. Patient-Reported measures for GI symptoms: a new role for the renin-angiotensin system of KC chemokine the! Marrow-Derived stem cells in liver cancer Dbaibo G, Hannun YA for cholestasis-induced fibrosis. 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