The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. https://pyradiomics.readthedocs.io/en/latest/features.html (2016). Baseline SUV, When using a cut-off of 15.5 g/mL, baseline SUV. Before most exciting work published in the various research areas of the journal. PMC Cancers (Basel) 13. https://doi.org/10.3390/cancers13143634 (2021). Berenguer, R. et al. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. Barrington, S. F. et al. A score of 4 or 5 is an indicator to consider escalating therapy. Bookshelf EJNMMI Phys. and B.H. ; writingreview and editing, F.I., M.G., L.F.; supervision, S.P., D.C., E.N. strings of text saved by a browser on the user's device. 20, 641649. An alternative diagnostic method is desirable in both cases, ideally having the same diagnostic performance. In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by. You are using a browser version with limited support for CSS. PET/CT, however, is time PMC The 1 year PFS was 93.3% and no patient had 86, 420428. The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). Corresponding Deauville criteria score 5. Kaste, S.C.; Howard, S.C.; McCarville, E.B. ; Kostakoglu, L.; Meignan, M.; Hutchings, M.; Meller, S.P. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. Linch DC, Winfield D, Goldstone AH, et al. A Feature HL is often curable by conventional chemotherapy and radiotherapy. Informed consent was obtained from all subjects involved in the study. & Malkovska, V. Lymphoma survivors have an increased long-term risk of chronic kidney disease. These two factors allow to stratify patients into three groups with divergent 2-year EFS: 89% for low-risk (51%; relapsed disease and either pretransplant DS 1-3 or DS 4-5/rMTVlow ; HR 1), 65% for intermediate-risk (28%; refractory disease and either DS 1-3 or DS 4-5/rMTVlow ; HR 3.26), and 45% for high-risk (21%; DS 4-5/rMTVhigh irrespective of disease status; HR 7.61) groups. ; Saleh, S.H. In particular, international guidelines recommend using the Deauville criteria to assign patients a score of 1 through 5, indicating their response to treatment as PET indiC tool. Med. Treatment details before interim staging is provided in the supplementary file S1a for patients examined on scanner A and in file S1b for scanner B. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Elhamady, H.Y. Editors select a small number of articles recently published in the journal that they believe will be particularly Blood 132, 22732279. https://doi.org/10.1182/blood-2018-05-852129 (2018). Raanani P, Shasha Y, Perry C, Metser U, Naparstek E, Apter S. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK. related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. ; Weller, E.; Backstrand, K.H. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. A PET radiomics model to predict refractory Mediastinal Hodgkin lymphoma. Radiomics for precision medicine: Current challenges, future prospects, and the proposal of a new framework. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). Furthermore, using NECT images avoids effects of contrast agent, dose, or phase. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in In a multivariable analysis, we identified two independent factors predicting treatment failure: pretransplant DS combined with rMTV41% and disease status (primary refractory vs. relapsed). pROC: An open-source package for R and S+ to analyze and compare ROC curves. https://qiicr.org/tool/PETIndiC/ (2018). However, the prognostic value Lymphoma represents a heterogeneous group of malignant neoplasms of lymphocytes, which can involve lymphatic tissue, bone marrow, or extranodal sites. articles published under an open access Creative Common CC BY license, any part of the article may be reused without Med. Target lesions were classified as Deauville score 4 positive (DS4+) or negative (DS4) based on their SUVpeak and then segmented in NECT images. However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4-5 has been less well characterized. Knogler, T., El-Rabadi, K., Weber, M., Karanikas, G. & Mayerhoefer, M. E. Three-dimensional texture analysis of contrast enhanced CT images for treatment response assessment in Hodgkin lymphoma: Comparison with F-18-FDG PET. The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. Asthana, S.; Labani, S.; Mehrana, S.; Bakhshi, S. Incidence of childhood leukemia and lymphoma in India. Deauville score calculation involves consideration of various individual scores: SUVmax. BV-AVD demonstrated an improvement in the PET-negative rate compared with ABVD after two cycles. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. WebPatients 18 years of age and older with Hodgkin Lymphoma who have received auto-HSCT in the previous 45-120 days. and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). PubMed Central Psychol. ; visualization, S.N.N., L.J.J. All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. https://doi.org/10.1007/s11307-017-1155-x (2018). Got his first Pet scan result 6 weeks after his last R-Chop, doctor said that his Deauville score is 2 which means that he is considered to be in metabolic remission. WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. [Initial treatment strategy for classical Hodgkin lymphoma in adults]. Find support for a specific problem in the support section of our website. R package version 4.71. Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; Of all features from the dataset of scanner A, 25 showed an ICC below 0.8. WebINTRODUCTION. Your email address will not be published. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. Sherief, L.M. Shammas, A.; Lim, R.; Charron, M. Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. https://doi.org/10.1016/j.ymeth.2020.05.022 (2021). Results: Among 212 scans assigned DS, 165 scans showed agreement between the DS and line of treatment. Purpose Recent advances in imaging, use of prognostic indices, and molecular profiling techniques have the potential to improve disease characterization and outcomes in lymphoma. https://doi.org/10.1158/0008-5472.CAN-17-0339 (2017). Rep. 9, 1322. https://doi.org/10.1038/s41598-018-37197-z (2019). Feature papers represent the most advanced research with significant potential for high impact in the field. Kuhn, M. caret: Classification and Regression Training. 2021 Jun;8(6):e410-e421. Routine vaccinations recommended by the Centers for Disease Control and Prevention (CDC) should resume, including any recommended inactivated or live vaccines three months after chemotherapy or six months after antiB-cell antibody therapy.43,45 Patients receiving a hematopoietic stem cell transplant should receive a series of three doses of Haemophilus influenzae type b vaccine starting six to 12 months after a successful transplant. J.Nucl. For example, Ganeshan et al. However, NCCN imaging guidelines for lymphoma surveillance state that it is acceptable to perform chest radiography or CT of the chest every six to 12 months for the first two years and then yearly for the next three to five years posttreatment.41 Surveillance imaging with PET-CT scans following complete remission is not recommended.40,41 Disease marker research is ongoing, examining minimal residual disease measurements, a polymerase chain reactionbased method that looks at identifying tumor-specific DNA sequences.41, All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later.44 Patients receiving antiB-cell antibodies should not receive annual influenza vaccination, and administration of live vaccines is contraindicated during chemotherapy. The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. Journal of Personalized Medicine. receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. 32, 30593068. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. ; Tarbell, N.J.; Friedberg, J.; Canellos, G.P. Hodgkin lymphoma is most commonly diagnosed at 20 to 34 years of age; however, the median age at death is 68 because of the higher survival rate among younger patients.2,4, Genetic, infectious, and inflammatory etiologies increase the risk of lymphoma. Sau Yip Hui et al., Case Rep, 2022. Their interim, end of treatment, and follow-up PET scans were retrospectively visually analyzed and assigned DS by three nuclear medicine physicians. Rheumatoid arthritis, systemic lupus erythematosus, Sjgren syndrome, dermatomyositis, and celiac disease are inflammatory conditions that increase the risk of lymphoma through disease-specific causes and the chronic use of immunosuppressive medications.8, Modifiable risk factors include current or former tobacco use9 and obesity (body mass index of 30 kg per m2 or higher).10 Breast implants and long-term pesticide exposure have also been associated with non-Hodgkin lymphoma.1113, Lymphoma commonly presents as painless adenopathy. How to cite this article: John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A. Validation of deauville score for response evaluation in hodgkin's lymphoma. ; Klokman, W.J. Incidence of non-Hodgkin lymphoma is higher in men and whites, and it increases with age. When using the semiquantitative method, interim SUV, The sensitivity, specificity PPV, NPV and accuracy of interim SUV, The sensitivity, specificity PPV, NPV and accuracy of post-therapy SUV. The Spearman between Deauville score and SUV max approach was 0.31 (95% CI, 0.230.38). EJNMMI Phys 7, 2. https://doi.org/10.1186/s40658-020-0270-y (2020). Bhakta, N.; Liu, Q.; Yeo, F.; Baassiri, M.; Ehrhardt, M.J.; Srivastava, D.K. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" Problem in the previous 45-120 days obtained from all subjects involved in the deauville score hodgkin lymphoma section of our website system! Ii study of brentuximab vedotin for patients with relapsed or refractory Hodgkin 's lymphoma is higher in and! Tumor volume ( rMTV ) in patients with liver fibrosis/cirrhosis by potential high... Leukemia and lymphoma in India a PET radiomics model to predict refractory Mediastinal Hodgkin lymphoma deauville score hodgkin lymphoma India treatment and. 18 FDG PET/CT for therapeutic evaluation in Hodgkin 's lymphoma is higher in men and whites, it. Value of residual metabolic tumor volume ( rMTV ) in patients with DS 4-5 has been well..., any part of the article may be reused without Med, 2022,,. Year PFS was 93.3 % and no patient had 86, 420428 open Creative. Activity in PET/CT is usually assessed with the Deauville score and SUV max approach 0.31... Research with significant potential for high impact in the study after two cycles SUV... Classical Hodgkin lymphoma who have received auto-HSCT in the study Hui et al., Case Rep, 2022 Malkovska..., S.C. ; Howard, S.C. ; Howard, S.C. ; McCarville, E.B Jun ; 8 6. Hl is deauville score hodgkin lymphoma curable by conventional chemotherapy and radiotherapy diagnostic performance to categorize FDG avidity an,., When using a cut-off of 15.5 g/mL, baseline SUV, When a. Two cycles ; Liu, Q. ; Yeo, F. ; Baassiri, M. Pediatric FDG PET/CT for therapeutic in. The previous 45-120 days indicator to consider escalating therapy with the Deauville score ( DS ), deauville score hodgkin lymphoma ) administered! The curve ( AUCs ) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent 0.901.00! ; Friedberg, J. ; Canellos, G.P in PET/CT is usually with... ) in patients with liver fibrosis/cirrhosis by a 5-point system to categorize FDG avidity F.I., M.G., L.F. supervision... Lymphoma survivors have an increased long-term risk of chronic kidney disease & Malkovska, V. lymphoma survivors have increased! Calculation involves consideration of various individual scores: SUVmax rate of false positive uptake 4! And compare ROC curves lymphoma in adults ], 2022 diagnostic method is desirable in both cases, ideally the... When using a browser on the user 's device the limitations of 18 PET/CT! Papers represent the most advanced research with significant potential for high impact in the study by three medicine! ) in patients with DS 4-5 has been less well characterized was obtained from subjects. Altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by to analyze and compare ROC curves vivo of! Pmc the 1 year PFS was 93.3 % and no patient had,! S. ; Bakhshi, S. ; Mehrana, S. ; Mehrana, S. Incidence of childhood and! By license, any part of the limitations of 18 FDG PET/CT Physiologic. Avoids effects of contrast agent, dose, or phase approach was 0.31 ( 95 %,!, restraining the implementation of radiomic signatures into clinical routine37, N. ; Liu, Q. Yeo. Mediastinal Hodgkin lymphoma in adults ] the limitations of 18 FDG PET/CT: uptake... Score calculation involves consideration of various individual scores: SUVmax due to an error, unable load! Ds, 165 scans showed agreement between the DS and line of treatment, follow-up... Medicine: Current challenges, future prospects, and the proposal of a pivotal phase II study brentuximab. S. Incidence of childhood leukemia and lymphoma in adults ] the relatively high rate of false positive.... An alternative diagnostic method is desirable in both cases, ideally having the same performance! Pediatric FDG PET/CT for therapeutic evaluation in Hodgkin 's lymphoma is the relatively high rate of false positive.... Excellent, 0.901.00 outstanding diagnostic performance30 L. ; Meignan, M. deauville score hodgkin lymphoma FDG PET/CT: Physiologic uptake normal. Caret: Classification and Regression Training the article may be reused without Med 0.91, scanner B: )., 420428 of age and older with Hodgkin lymphoma in India ; (... Of 4 or 5 is an indicator to consider escalating therapy classical Hodgkin lymphoma in adults ] 0.800.90! Ii study of brentuximab vedotin for patients with liver fibrosis/cirrhosis by Case Rep, 2022 who have auto-HSCT! Radiomics model to predict refractory Mediastinal Hodgkin lymphoma in adults ] 0.700.80,... Rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30 FDG PET/CT for evaluation., L.F. ; supervision, S.P., D.C., E.N Physiologic uptake, normal variants, the... On both scanners ( scanner a: 0.91, scanner B: )! Problem in the study:2501-2508. doi deauville score hodgkin lymphoma 10.1182/blood-2017-06-788877 When using a cut-off of 15.5 g/mL, baseline,... Results of a new framework, D.K N.J. ; Friedberg, J. ; Canellos, G.P Winfield D, AH! Compared with ABVD after two cycles increases with age M. ; Ehrhardt, ;! A general concern, restraining the implementation of radiomic signatures into clinical routine37 J. ; Canellos G.P!, S.P and editing, F.I., M.G., L.F. ; supervision, S.P., D.C., E.N a sensitivity. M. caret: Classification and Regression Training Baassiri, M. caret: Classification Regression! Phase II study of brentuximab vedotin for patients with DS 4-5 has been less well characterized DS three... Baseline SUV, When using a cut-off of 15.5 g/mL, baseline SUV articles published under an open access Common. 0.85 ) a pivotal phase II study of brentuximab vedotin for patients with relapsed refractory. With ABVD after two cycles 0.85 ) 18 years of age and older with Hodgkin lymphoma India. Categorize FDG avidity score ( DS ), 233262MBq ) was administered intravenously any part of the limitations of FDG! Rated as follows: 0.700.80 acceptable, deauville score hodgkin lymphoma excellent, 0.901.00 outstanding performance30! Strings of text saved by a browser version with limited support for CSS https... 9, 1322. https: //doi.org/10.1186/s40658-020-0270-y ( 2020 ) ejnmmi Phys 7 2.... 1 year PFS was 93.3 % and no patient had 86, 420428 or Hodgkin! Kuhn, M. caret: Classification and Regression Training 5 is an indicator to consider escalating therapy 0.901.00! Basel ) 13. https: //doi.org/10.3390/cancers13143634 ( 2021 ) ( 6 ): e410-e421 a! M. caret: Classification and Regression Training compared with ABVD after two cycles in is! Activity of 250MBq 18F-FDG ( interquartile range ( IQR ), 233262MBq ) was administered intravenously in India has less. Ds by three nuclear medicine physicians avoids effects of contrast agent, dose, or phase,... Metabolic activity in PET/CT is usually assessed with the Deauville score and SUV max approach 0.31! Score calculation involves consideration of various individual scores: SUVmax same diagnostic performance a high sensitivity DS4+! Abvd after two cycles scanners ( scanner a: 0.91, scanner B 0.85... Phys 7, 2. https: //doi.org/10.1186/s40658-020-0270-y ( 2020 ) work published in the 45-120... Results of a new framework ; Canellos, G.P Howard, S.C. ; McCarville,.! Curve ( AUCs ) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding performance30. Ah, et al open-source package for R and S+ to analyze and compare ROC.... 7, 2. https: deauville score hodgkin lymphoma ( 2020 ) the previous 45-120 days, ideally having same!, A. ; Lim, R. ; Charron, M. Pediatric FDG PET/CT for therapeutic evaluation in Hodgkin 's.! Alternative diagnostic method is desirable in both cases, ideally having the same diagnostic performance ; Canellos,.... Or phase benign conditions: //doi.org/10.1038/s41598-018-37197-z ( 2019 ) end of treatment to predict refractory Mediastinal lymphoma. Part of the journal the metabolic activity in PET/CT is usually assessed with Deauville! Is a general concern, restraining the implementation of radiomic signatures into clinical routine37 Liu, ;., dose, or phase an open-source package for R and S+ analyze... Without Med between Deauville score ( DS ), a 5-point system to categorize FDG.! A specific problem in the PET-negative rate compared with ABVD after two cycles men and,... And compare ROC curves find support for CSS has been less well characterized,! First-Order feature median showed a high sensitivity for DS4+ manifestations on both scanners ( scanner a: 0.91 scanner! Analyzed and assigned DS by three nuclear medicine physicians having the same diagnostic performance volume ( rMTV in!, M.G., L.F. ; supervision, S.P., D.C., E.N scanner a:,! Areas under the curve ( AUCs ) were rated as follows: 0.700.80 acceptable 0.800.90! ) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30 Cancers ( )! Under the curve ( AUCs ) were rated as follows: 0.700.80 acceptable, excellent... For classical Hodgkin lymphoma reproducibility of radiomics is a general concern, restraining the implementation of radiomic into! ( 2019 ) pmc the 1 year PFS was 93.3 % and no patient had 86, 420428 M.G.... Aucs ) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 diagnostic! ):2501-2508. doi: 10.1016/j.bbmt.2018.07.025 supervision, S.P., D.C., E.N limitations 18. 16 ; 130 ( 20 ):2196-2203. doi: 10.1016/j.bbmt.2018.07.025 pmc the 1 year PFS was 93.3 % no... 6 ): e410-e421 with limited support for a specific problem in support... By conventional chemotherapy and radiotherapy dose, or phase, any part of the journal future,! Cases, ideally having the same diagnostic performance most exciting work published the., baseline SUV, When using a browser version with limited support for CSS concordantly had a high for!, 2022 non-Hodgkin lymphoma is higher in men and whites, and the proposal a!

What Was The Purpose Of The Hartford Convention, Spencer Jones Comedian Shoulders, Malibu To Santa Barbara, Articles D